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Dkk3 Gene Detail
Summary
  • Symbol
    Dkk3
  • Name
    dickkopf WNT signaling pathway inhibitor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354952
    NCBI Gene: 50781
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:111715224-111758264 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 58.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354952
 protein coding gene Chr7:111715224-111758689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032867
 protein coding gene Chr7:115670686-115717571 (-)
A/J MGP_AJ_G0032850
 protein coding gene Chr7:112794543-112838199 (-)
AKR/J MGP_AKRJ_G0032782
 protein coding gene Chr7:115629074-115673528 (-)
BALB/cJ MGP_BALBcJ_G0032855
 protein coding gene Chr7:112473042-112517980 (-)
C3H/HeJ MGP_C3HHeJ_G0032565
 protein coding gene Chr7:115622595-115670235 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033361
 protein coding gene Chr7:120408164-120459329 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030333
 protein coding gene Chr7:114394982-114438202 (-)
CAST/EiJ MGP_CASTEiJ_G0031893
 protein coding gene Chr7:107231113-107276036 (-)
CBA/J MGP_CBAJ_G0032538
 protein coding gene Chr7:124359588-124414601 (-)
DBA/2J MGP_DBA2J_G0032690
 protein coding gene Chr7:110880081-110924531 (-)
FVB/NJ MGP_FVBNJ_G0032643
 protein coding gene Chr7:110727093-110772210 (-)
LP/J MGP_LPJ_G0032784
 protein coding gene Chr7:117179559-117224839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032675
 protein coding gene Chr7:125974266-126021977 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033381
 protein coding gene Chr7:114634994-114678264 (-)
PWK/PhJ MGP_PWKPhJ_G0031600
 protein coding gene Chr7:103717140-103759880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031448
 protein coding gene Chr7:101387804-101429633 (-)
WSB/EiJ MGP_WSBEiJ_G0032006
 protein coding gene Chr7:115494344-115538830 (-)



Homology
more
  • Human Ortholog
    DKK3, dickkopf WNT signaling pathway inhibitor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKK3, dickkopf WNT signaling pathway inhibitor 3
  • Synonyms
    CRRL, REIC, RIG
  • Links
    NCBI Gene ID: 27122
    neXtProt AC: NX_Q9UBP4
    UniProt: Q9UBP4

  • Chr Location
    11p15.3; chr11:11956207-12009769 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and euthyroid but exhibit hyperactivity, a slight but significant decrease in the frequency of natural killer cells, and significantly increased IgM, hemoglobin, and hematocrit levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1366
  • Tissues
    419
  • cDNA Data
    14
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030772 Ensembl Gene Model | MGI Sequence Detail 43041 C57BL/6J ±  kb
    transcript ENSMUST00000033036 Ensembl | MGI Sequence Detail 3359 Not Applicable  
    polypeptide ENSMUSP00000033036 Ensembl | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006501 dickkopf-related protein 3
      (term hierarchy)
    • InterPro Domains
      IPR006796 Dickkopf, N-terminal cysteine-rich
      IPR039863 Dickkopf related protein 1-4
      IPR047301 Dickkopf-related protein 3, N-terminal domain
      IPR047300 Dickkopf-related protein 3, second cysteine-rich domain
    • GlyGen
      Q9QUN9 4 sites, 7 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 19
      Primer pair 12
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142202, MGI:2142371
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 62
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
    • Latest
      J:348700 Hu L, et al., Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice. Cell Death Dis. 2024 May 17;15(5):343
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory