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Tnfsf14 Gene Detail
Summary
  • Symbol
    Tnfsf14
  • Name
    tumor necrosis factor (ligand) superfamily, member 14
  • Synonyms
    HVEM-L, LIGHT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355317
    NCBI Gene: 50930
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57496492-57501177 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.71 cM, cytoband D-E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355317
 protein coding gene Chr17:57496437-57501182 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023958
 protein coding gene Chr17:58954907-58959604 (-)
A/J MGP_AJ_G0023916
 protein coding gene Chr17:57317800-57322498 (-)
AKR/J MGP_AKRJ_G0023885
 protein coding gene Chr17:58048199-58052896 (-)
BALB/cJ MGP_BALBcJ_G0023917
 protein coding gene Chr17:57158861-57163558 (-)
C3H/HeJ MGP_C3HHeJ_G0023681
 protein coding gene Chr17:58765454-58770151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024363
 protein coding gene Chr17:61248428-61253125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021809
 protein coding gene Chr17:53788725-53793558 (-)
CAST/EiJ MGP_CASTEiJ_G0023163
 protein coding gene Chr17:59075565-59080276 (-)
CBA/J MGP_CBAJ_G0023657
 protein coding gene Chr17:63645024-63649721 (-)
DBA/2J MGP_DBA2J_G0023785
 protein coding gene Chr17:56010743-56015440 (-)
FVB/NJ MGP_FVBNJ_G0023751
 protein coding gene Chr17:55589725-55594422 (-)
LP/J MGP_LPJ_G0023867
 protein coding gene Chr17:59640327-59645024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023779
 protein coding gene Chr17:63075542-63080239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024407
 protein coding gene Chr17:58407897-58412594 (-)
PWK/PhJ MGP_PWKPhJ_G0022909
 protein coding gene Chr17:55382848-55387536 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022720
 protein coding gene Chr17:55181199-55185910 (-)
WSB/EiJ MGP_WSBEiJ_G0023229
 protein coding gene Chr17:59044556-59049268 (-)



Homology
more
  • Human Ortholog
    TNFSF14, TNF superfamily member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF14, TNF superfamily member 14
  • Synonyms
    CD258, HVEML, LIGHT, LTg
  • Links
    NCBI Gene ID: 8740
    neXtProt AC: NX_O43557
    UniProt: O43557

  • Chr Location
    19p13.3; chr19:6661253-6670588 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfsf14 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 5 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene leads to selective impairment of CD8+ T cell function. Mice homozygous for a knock-out allele exhibit defects in CD8+ T cell-mediated allogenic responses. Mice homozygous for a different knock-out allele show increased resistance to experimentally-induced hepatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005824 Ensembl Gene Model | MGI Sequence Detail 4686 C57BL/6J ±  kb
    transcript ENSMUST00000005976 Ensembl | MGI Sequence Detail 1847 Not Applicable  
    polypeptide ENSMUSP00000005976 Ensembl | MGI Sequence Detail 239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 107
      Diseases 1
      Gene Ontology 12
      Phenotypes 60
    • Earliest
      J:60454 Matsumoto M, Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest. 1999 Aug;46(3-4):141-50
    • Latest
      J:337669 Seo GY, et al., Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. Sci Immunol. 2022 Jul 29;7(73):eabm6931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory