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Nckap1 Gene Detail
Summary
  • Symbol
    Nckap1
  • Name
    NCK-associated protein 1
  • Synonyms
    H19, Hem-2, Hem2, mh19, Nap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355333
    NCBI Gene: 50884
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:80330856-80411526 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 48.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1796 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355333
 protein coding gene Chr2:80330856-80411724 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025885
 protein coding gene Chr2:81083996-81168142 (-)
A/J MGP_AJ_G0025862
 protein coding gene Chr2:77961309-78043909 (-)
AKR/J MGP_AKRJ_G0025831
 protein coding gene Chr2:79996687-80080715 (-)
BALB/cJ MGP_BALBcJ_G0025858
 protein coding gene Chr2:78087850-78172214 (-)
C3H/HeJ MGP_C3HHeJ_G0025617
 protein coding gene Chr2:80233121-80318200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026304
 protein coding gene Chr2:83470184-83558999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023707
 protein coding gene Chr2:75171546-75252502 (-)
CAST/EiJ MGP_CASTEiJ_G0025079
 protein coding gene Chr2:80671825-80758346 (-)
CBA/J MGP_CBAJ_G0025598
 protein coding gene Chr2:86497611-86590186 (-)
DBA/2J MGP_DBA2J_G0025729
 protein coding gene Chr2:77502945-77586953 (-)
FVB/NJ MGP_FVBNJ_G0025691
 protein coding gene Chr2:76847887-76932704 (-)
LP/J MGP_LPJ_G0025817
 protein coding gene Chr2:80942319-81031917 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025722
 protein coding gene Chr2:88356978-88472637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026360
 protein coding gene Chr2:80161649-80246613 (-)
PWK/PhJ MGP_PWKPhJ_G0024822
 protein coding gene Chr2:77444657-77529684 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024628
 protein coding gene Chr2:80413182-80496445 (-)
WSB/EiJ MGP_WSBEiJ_G0025148
 protein coding gene Chr2:80801175-80898077 (-)



Homology
more
  • Human Ortholog
    NCKAP1, NCK associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCKAP1, NCK associated protein 1
  • Synonyms
    HEM2, NAP1, NAP125, p125Nap1
  • Links
    NCBI Gene ID: 10787
    neXtProt AC: NX_Q9Y2A7
    UniProt: Q9Y2A7

  • Chr Location
    2q32.1; chr2:182909115-183038858 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit growth arrest at midgestation, an open neural tube, cardia bifida, defective foregut development, defects in endoderm and mesoderm migration and sometimes duplication of the anteroposterior body axis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    73
  • cDNA Data
    294
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50884 NCBI Gene Model | MGI Sequence Detail 80671 C57BL/6J ±  kb
    transcript NM_001290745 RefSeq | MGI Sequence Detail 4421 ZRU/MplStud  
    polypeptide P28660 UniProt | EBI | MGI Sequence Detail 1128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 295
      cDNA 294
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139487
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory