Tyrp1<b> Spontaneous Allele Detail MGI Mouse (MGI:1855960)

Tyrp1^b
Spontaneous Allele Detail

Summary

Symbol:	Tyrp1^b
Name:	tyrosinase-related protein 1; brown
MGI ID:	MGI:1855960
Synonyms:	b
Gene:	Tyrp1 Location: Chr4:80752360-80769956 bp, + strand Genetic Position: Chr4, 37.89 cM
Alliance:	Tyrp1^b page

a/a Tyrp1^b/Tyrp1^b

Show the 5 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

old mutant of the mouse fancy

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation changes cysteine to tyrosine at position 110 (p.C110Y) in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. (J:44435)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tyrp1^b

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 29 strains available Cell Lines: 0 lines available
Carrying any Tyrp1 Mutation:	162 strains or lines available

References

Original:	J:30758 Gruneberg H, The Genetics of the Mouse, second edition, in The Genetics of the Mouse. 1952
All:	38 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24