Axin1<Fu> Spontaneous Allele Detail MGI Mouse (MGI:1856035)

Axin1^Fu
Spontaneous Allele Detail

Summary

Symbol:	Axin1^Fu
Name:	axin 1; fused
MGI ID:	MGI:1856035
Synonyms:	Fu, T^f
Gene:	Axin1 Location: Chr17:26357662-26414785 bp, + strand Genetic Position: Chr17, 13.07 cM
Alliance:	Axin1^Fu page

Mutation
origin

Strain of Origin:

Bussey Institution stock

Mutation
description

Allele Type:		Spontaneous
Mutation:		Transposon insertion
		Mutation details: The mutation is an IAP retrotransposon insertion within the sixth intron that results in the production of wild-type transcripts as well as mutant transcripts that initiate at both the authentic promoter and the 3'-most long terminal repeat of the insertion. (J:41619, J:43298, J:72363)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Axin1 Mutation:	44 strains or lines available

Notes

Gametic imprinting has been detected for Axin1^Fu (J:11139), and the locus may be affected by inherited inactivation (J:6577). Penetrance is affected by the genetic background, although expressivity is not. A suppressor gene in C57BL/6 decreases the penetrance of Axin1^Fu in hybrids (J:11139). The suppressor gene did not affect penetrance of Axin1^Fu in mice chimeric between C57BL/6 and a stock carrying Axin1^Fu (J:19657).

References

Original:	J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
All:	19 reference(s)

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