Mgrn1<md> Spontaneous Allele Detail MGI Mouse (MGI:1856070)

Mgrn1^md
Spontaneous Allele Detail

Summary

Symbol:	Mgrn1^md
Name:	mahogunin, ring finger 1; mahoganoid
MGI ID:	MGI:1856070
Synonyms:	md
Gene:	Mgrn1 Location: Chr16:4704113-4756160 bp, + strand Genetic Position: Chr16, 2.48 cM, cytoband A1
Alliance:	Mgrn1^md page

Mgrn1^md/+ and Mgrn1^md/Mgrn1^md

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C3H/HeJ

Mutation
description

Allele Type:		Spontaneous
Mutation:		Transposon insertion
		Mutation details: The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. (J:80182)
Inheritance:		Recessive

Schematic of the location of the IAP insertion generating the Mgrn1^md allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available
Carrying any Mgrn1 Mutation:	55 strains or lines available

Notes

The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrn^mg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).

References

Original:	J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24