Mitf<mi-bw> Spontaneous Allele Detail MGI Mouse (MGI:1856089)

Mitf^mi-bw
Spontaneous Allele Detail

Summary

Symbol:	Mitf^mi-bw
Name:	melanogenesis associated transcription factor; black eyed white
MGI ID:	MGI:1856089
Gene:	Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
Alliance:	Mitf^mi-bw page

Mutation
origin

Strain of Origin:

C3H

Mutation
description

Allele Type:		Spontaneous
Mutation:		Transposon insertion
		Mutation details: This allele comprises a 7.2 kb novel L1 element insertion into intron sequences located between exons 3 and 4. This insertion reduces the amount of mRNAs for two splicing isoforms of this gene and abolishes expression of a third isoform. (J:56633)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Mitf Mutation:	74 strains or lines available

References

Original:	J:13071 Kreitner PC, Linkage studies in a new black-eyed white mutation in the house mouse (not W). J Hered. 1957;48(6):300-304
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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