Kitl<Sl> Spontaneous Allele Detail MGI Mouse (MGI:1856161)

Kitl^Sl
Spontaneous Allele Detail

Summary

Symbol:	Kitl^Sl
Name:	kit ligand; steel
MGI ID:	MGI:1856161
Synonyms:	Mgf^Sl, Sl
Gene:	Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
Alliance:	Kitl^Sl page

Pax3^Sp/+ and Kitl^Sl/+

Show the 2 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

C3H

Mutation
description

Allele Type:		Spontaneous
Mutation:		Deletion
		Kitl^Sl involves 1 genes/genome features (Kitl) View all
		Mutation details: By Southern blotting, it was concluded that this allele contains a deletion encompassing most, if not all, of the coding region of the gene. A probe corresponding to nucleotides 6 to 685 of the cDNA failed to hybridize to DNA obtained from embryos homozygous for this allele. PCR analysis with primers for sequences at various distances from the Kit gene narrowed the 5' and 3' deletion endpoints to a 350 and a 380 base-pair region, respectively. Sequencing of the product of PCR using primers designed to span the deletion revealed that it extends through 973,366 base pairs on Chromosome 10 between nucleotide positions 99,177,807 and 100,151,173 (NCBI Map Viewer, Build 36.1), with a 4-base pair insertion joining the deletion endpoints, and contains 6 predicted and 3 known genes. (J:10750, J:115283)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

18 assay results
2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Kitl^Sl

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Kitl Mutation:	94 strains or lines available

References

Original:	J:3399 Sarvella PA, et al., Steel, a new dominant gene in the house mouse: With effects on coat pigment and blood. J Hered. 1956;47(3):123-128
All:	74 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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