Kitl<Sl-con> Radiation induced Allele Detail MGI Mouse (MGI:1856163)

Kitl^Sl-con
Radiation induced Allele Detail

Summary

Symbol:	Kitl^Sl-con
Name:	kit ligand; steel contrasted
MGI ID:	MGI:1856163
Synonyms:	Mgf
Gene:	Kitl Location: Chr10:99851492-99936278 bp, + strand Genetic Position: Chr10, 51.4 cM
Alliance:	Kitl^Sl-con page

Mutation
origin

Strain of Origin:

(C3H/HeH x 101/H)F1

Mutation
description

Allele Type:		Radiation induced
Mutation:		Other
		Mutation details: Pulse field gel electrophoresis using cDNA and genomic clones showed that this allele is an undefined rearrangement between 90 and 2.2Mb 5' to Kitl. Northern analysis showed that the mRNA transcript is of normal size but this allele exerts tissue-specific effects on transcript abundance. (J:23593)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Kitl Mutation:	94 strains or lines available

Notes

The contrasted mutation was found in a neutron irradiation experiment. Heterozygotes are recognizable soon after birth by dark pigmentation of the genital papilla. The adult coat is slightly lighter than normal. Homozygotes also have dark external genitalia but a markedly diluted coat; they have a mild macrocytic anemia. Males are fertile but females are usually sterile (J:20215).

References

Original:	J:20215 Searle AG, New mutant (Contrasted). Mouse News Lett. 1968;38:22
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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