Otc<spf> Radiation induced Allele Detail MGI Mouse (MGI:1856178)

Otc^spf
Radiation induced Allele Detail

Summary

Symbol:	Otc^spf
Name:	ornithine transcarbamylase; sparse fur
MGI ID:	MGI:1856178
Synonyms:	spf
Gene:	Otc Location: ChrX:10118584-10187275 bp, + strand Genetic Position: ChrX, 4.66 cM, cytoband A1
Alliance:	Otc^spf page

Otc^spf/Otc^spf

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Radiation induced (Hypomorph)
Mutation:		Single point mutation
		Mutation details: A C to A missense transversion mutation in exon 4 changes a histidine to asparagine (H117N), creating a hypomorphic allele. About 10% of normal liver enzyme activity remains in mutant mice. (J:8786)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available Cell Lines: 0 lines available
Carrying any Otc Mutation:	22 strains or lines available

References

Original:	J:26975 Cupp MB, Sparse-fur, Sf. Mouse News Lett. 1958;19:37
All:	33 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24