Pax1<un> Spontaneous Allele Detail MGI Mouse (MGI:1856222)

About Help FAQ

Pax1^un
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Pax1^un
Name:	paired box 1; undulated
MGI ID:	MGI:1856222
Synonyms:	un
Gene:	Pax1 Location: Chr2:147203850-147216972 bp, + strand Genetic Position: Chr2, 72.63 cM
Alliance:	Pax1^un page

Mutation
origin

Strain of Origin:

fancier's mice

Mutation
description

Allele Type:		Spontaneous
Mutation:		Nucleotide substitutions
		Mutation details: A point mutation results in a substitution of glycine for serine at position 15 of the paired box motifand markedly decreases the DNA-binding ability of the Pax1 protein and changes its DNA specificity. (J:9424)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available Cell Lines: 0 lines available
Carrying any Pax1 Mutation:	28 strains or lines available

References

Original:	J:314 Wright ME, Undulated: a new genetic factor in Mus musculus affecting the spine and tail. Heredity. 1947;1(1):137-41
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24