Grem1<ld> Radiation induced Allele Detail MGI Mouse (MGI:1856289)

Grem1^ld
Radiation induced Allele Detail

Summary

Symbol:	Grem1^ld
Name:	gremlin 1, DAN family BMP antagonist; limb deformity
MGI ID:	MGI:1856289
Synonyms:	Fmn^ld, Fmn^ld-Or, ld, ld^OR
Gene:	Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
Alliance:	Grem1^ld page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Radiation induced
Mutation:		Intragenic deletion
		Mutation details: This mutant allele was recovered at The Oak Ridge National Laboratory among descendants of an X-irradiated male. The allele contains a 12.7 kb deletion that eliminates the entire open reading frame encoded by exon 2. (J:13658, J:43337, J:91385)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Grem1 Mutation:	19 strains or lines available

Notes

Possibly radiation induced (found in later generation descendants of X-irradiated male).

Originally called "severe appendicular abnormality."

This limb deformity allele was determined through complementation analysis to be allelic to limb deformity Jackson (Grem1^ld-J; J:22160), Fmn1^ld-TgBri137 (J:1741), and Fmn1^{ld-Is(17;In2)1Gso} (J:10399).

References

Original:	J:22158 Cupp MB, Severe appendicular abnormality. Mouse News Lett. 1958;19:37
All:	16 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24