Dct<slt> Spontaneous Allele Detail MGI Mouse (MGI:1856379)

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Dct^slt
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Dct^slt
Name:	dopachrome tautomerase; slaty
MGI ID:	MGI:1856379
Synonyms:	slt
Gene:	Dct Location: Chr14:118250202-118289656 bp, - strand Genetic Position: Chr14, 61.6 cM
Alliance:	Dct^slt page

Mutation
origin

Strain of Origin:

STOCK Grem1^ld-J Atrn^mg

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: Sequence analysis showed this allele involves a G-to-A transition (C-to-T on forward strand) at coding nucleotide 581 which results in a arginine to glutamine missense mutation at position 194 (p.R194Q). The mutation reduces but does not eliminate enzyme activity. (J:1961)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Dct Mutation:	35 strains or lines available

References

Original:	J:13534 Green MC, Slaty (slt). Mouse News Lett. 1972;47:36
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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