Tgfa<wa1> Spontaneous Allele Detail MGI Mouse (MGI:1856388)

Tgfa^wa1
Spontaneous Allele Detail

Summary

Symbol:	Tgfa^wa1
Name:	transforming growth factor alpha; waved 1
MGI ID:	MGI:1856388
Synonyms:	wa-1, waved
Gene:	Tgfa Location: Chr6:86172205-86252701 bp, + strand Genetic Position: Chr6, 37.62 cM
Alliance:	Tgfa^wa1 page

Mutation
origin

Strain of Origin:

Not Specified

Mutation
description

Allele Type:		Spontaneous
Mutation:		Undefined
		Mutation details: This allele was identified by a noncomplementation test with Tgfa^tm1Unc. Although the specific molecular lesion has not been identified, Northern blot analysis revealed that expression of TGFalpha transcript was reduced in homozygous mice. (J:4605)
Inheritance:		Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tgfa^wa1/Tgfa^wa1	Not Specified

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
immune system	√
conjunctivitis	√
keratoconjunctivitis	√
integument	√
abnormal coat/ hair morphology	√
abnormal coat appearance	√
abnormal hair texture	√
waved hair	√
decreased guard hair length	√
abnormal hair shaft morphology	√
increased curvature of hairs	√
abnormal zigzag hair morphology	√
abnormal hair follicle development	√
abnormal vibrissa morphology	√
wavy vibrissae	√
vision/eye	√
conjunctivitis	√
keratoconjunctivitis	√
abnormal cornea stroma development	√
increased cornea stroma thickness	√
cornea opacity	√
cornea scarring	√
failure of eyelid fusion	√
microphthalmia	√
eyelids open at birth	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Tgfa Mutation:	18 strains or lines available

References

Original:	J:13034 Crew FAE, Waved: an autosomal recessive coat form character in the mouse. J Genet. 1933;27(1):95-96
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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