Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Lepob Name: leptin; obese MGI ID: MGI:1856424 Synonyms: ob, ob/ob Gene: Lep  Location: Chr6:29060220-29073875 bp, + strand  Genetic Position: Chr6, 12.3 cM Alliance: Lepob page

Lepob/Lepob Show the 5 phenotype image(s) involving this allele.

Strain of Origin:

STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allele Type:    Spontaneous (Null/knockout) Mutation:    Single point mutation   Mutation details: Sequencing of RT-PCR products revealed a nonsense mutation in arginine codon 105 (p.R105*) resulting from a C-to-T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). (J:20512, J:29081, J:45748) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	72 assay results 25 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

List all tumor models in MMHCdb carrying Lepob

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Lep Mutation:	21 strains or lines available

Original:	J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
All:	1615 reference(s)