Foxn1<nu-Y> Spontaneous Allele Detail MGI Mouse (MGI:1856502)

Foxn1^nu-Y
Spontaneous Allele Detail

Summary

Symbol:	Foxn1^nu-Y
Name:	forkhead box N1; nude Yurlovo
MGI ID:	MGI:1856502
Gene:	Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
Alliance:	Foxn1^nu-Y page

Mutation
origin

Strain of Origin:

101/HY

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: A point mutation resulting in the C-to-T transition at nucleotide 1051 (accession# X81593) located in exon 7, leads to the replacement of an arginine with a cysteine at amino acid 320 (p.R320C). Although mutant protein is detectable in the nucleus, there was no detectable activation of the Krt2-18 target gene. (J:61394)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:	106 strains or lines available

References

Original:	J:4060 Ignat'eva EL, et al., Athymic Mice of Inbred Strain 101/Hy with a New Allele at the Nude Locus. Biull Eksp Biol Med. 1992;113(1):111-4
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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