Foxc1<ch> Spontaneous Allele Detail MGI Mouse (MGI:1856705)

Foxc1^ch
Spontaneous Allele Detail

Summary

Symbol:	Foxc1^ch
Name:	forkhead box C1; congenital hydrocephalus
MGI ID:	MGI:1856705
Synonyms:	ch, mf1^ch
Gene:	Foxc1 Location: Chr13:31990629-31994618 bp, + strand Genetic Position: Chr13, 13.52 cM
Alliance:	Foxc1^ch page

Foxc1^ch/Foxc1^ch

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

Mutation
description

Allele Type:		Spontaneous
Mutation:		Single point mutation
		Mutation details: A transition point mutation at coding nucleotide 367 altered a C to a T in the coding region. This results in a stop codon in place of glutamine codon 123 (p.Q123) in the sequences encoding the third helix of the WH domain. The authors predict that a truncated protein would be generated lacking DNA binding activity. (J:48079*)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	77 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Foxc1 Mutation:	29 strains or lines available

References

Original:	J:75733 Gruneberg H, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism. J Genet. 1943;45(1):1-21
All:	22 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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