Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ay Name: nonagouti; agouti yellow MGI ID: MGI:1856798 Synonyms: A(y), Ay, lethal yellow Gene: a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM Alliance: Ay page

Ay/a mouse Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

old mutant of the mouse fancy

Allele Type:    Spontaneous Mutation:    Other   Mutation details: The Ay mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between Ay and the a and ax alleles suggests that Ay was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical. (J:8877, J:12911, J:17512, J:18921) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

List all tumor models in MMHCdb carrying Ay

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:	463 strains or lines available

Original:	J:12954 Dunn LC, et al., Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics. 1937 Mar;22(2):307-18
All:	196 reference(s)