Tmc1<dn> Spontaneous Allele Detail MGI Mouse (MGI:1856845)

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Tmc1^dn
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Tmc1^dn
Name:	transmembrane channel-like gene family 1; deafness
MGI ID:	MGI:1856845
Synonyms:	dn
Gene:	Tmc1 Location: Chr19:20760822-20931566 bp, - strand Genetic Position: Chr19, 13.98 cM, cytoband B
Alliance:	Tmc1^dn page

Mutation
origin

Strain of Origin:

STOCK Grhl3^ct/J

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion
		Mutation details: The mutation is a 1656 bp deletion including exon 14 and flanking intronic sequences. RT-PCR analysis confirmed that an mRNA was made that spliced exon 13 sequences in frame to exon 15 sequences. (J:75142)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Tmc1 Mutation:	59 strains or lines available

References

Original:	J:236 Deol MS, et al., A new gene for deafness in the mouse. Heredity. 1958;12(4):463-6
All:	31 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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