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Ctslfs
Spontaneous Allele Detail
Summary
Symbol: Ctslfs
Name: cathepsin L; furless
MGI ID: MGI:1856878
Gene: Ctsl  Location: Chr13:64509704-64518586 bp, - strand  Genetic Position: Chr13, 33.26 cM
Alliance: Ctslfs page
Mutation
origin
Strain of Origin:  unpedigreed stock
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation details: The mutation in the furless mutant was identified as a G-to-A transition (C-to-T on forward strand) in exon 5, resulting in an glycine to arginine substitution at position 149 of the protein (p.G149R). (J:70118)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctsl Mutation:  32 strains or lines available
Notes
The phenotype of homozygous furless mice was notably similar to the phenotype observed in Ctsltm1Cptr homozygous mice. An allele test between the two mutant strains of mice was performed, where they failed to complement, indicating the two mutants are allelic.
References
Original:  J:15332 Green EL, The genetics of a new hair deficiency, furless, in the house mouse. J Hered. 1954;45(3):115-18
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory