Dll3<pu> Radiation induced Allele Detail MGI Mouse (MGI:1857008)

Dll3^pu
Radiation induced Allele Detail

Summary

Symbol:	Dll3^pu
Name:	delta like canonical Notch ligand 3; pudgy
MGI ID:	MGI:1857008
Synonyms:	pu
Gene:	Dll3 Location: Chr7:27992980-28001210 bp, - strand Genetic Position: Chr7, 16.67 cM
Alliance:	Dll3^pu page

control and Dll3^pu/Dll3^pu

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Strain of Origin:

(101/Rl x C3H/Rl)F1

Mutation
description

Allele Type:		Radiation induced
Mutation:		Intragenic deletion
		Mutation details: Sequencing of Dll3 shows that Dll3^pu mutants have a 4 bp deletion in the third exon leading to a frameshift and early truncation of the expected Dll3 product ahead of the conserved DSL domain. (J:48518)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	80 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Dll3 Mutation:	42 strains or lines available

Notes

The pudgy mutation appeared in descendants of an X-rayed male at the Oak Ridge National Laboratory. (J:14975). It has been suggested that Dll3^pu may be a recurrence of stub (sb), a skeletal mutant now extinct (J:245).

References

Original:	J:14975 Gruneberg H, Genetical studies on the skeleton of the mouse. XXIX. Pudgy. Genet Res. 1961;2(3):384-93
All:	18 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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