Wnt7a<px> Spontaneous Allele Detail MGI Mouse (MGI:1857009)

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Wnt7a^px
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Wnt7a^px
Name:	wingless-type MMTV integration site family, member 7A; postaxial hemimelia
MGI ID:	MGI:1857009
Synonyms:	px
Gene:	Wnt7a Location: Chr6:91340963-91388335 bp, - strand Genetic Position: Chr6, 40.45 cM
Alliance:	Wnt7a^px page

Mutation
origin

Strain of Origin:

STOCK Sox18^Ra

Mutation
description

Allele Type:		Spontaneous
Mutation:		Intragenic deletion
		Mutation details: A 515 bp deletion at the end of exon 3. This results in utilization of a cryptic splice site in exon 3. This alteration in the mRNA is predicted to create a shift in the reading frame and the introduction of a stop codon at the beginning of the fourth exon. (J:50461)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Wnt7a Mutation:	26 strains or lines available

References

Original:	J:112 Searle AG, The genetics and morphology of two 'luxoid' mutants in the house mouse. Genet Res. 1964;5(2):171-197
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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