Myo15a<sh2> Radiation induced Allele Detail MGI Mouse (MGI:1857036)

Myo15a^sh2
Radiation induced Allele Detail

Summary

Symbol:	Myo15a^sh2
Name:	myosin XVA; shaker 2
MGI ID:	MGI:1857036
Synonyms:	sh2
Gene:	Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
Alliance:	Myo15a^sh2 page

Mutation
origin

Strain of Origin:

Mixed stock

Mutation
description

Allele Type:		Radiation induced
Mutation:		Single point mutation
		Mutation details: The sequences of all 49 exons of this gene were analyzed. A G to A transition was found in codon 674 within exon 18 that produces a Cys to Tyr substitution that likely removes an actin binding site. (J:48001)
Inheritance:		Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

Phenotypes:

Affected Systems	hm1	hm2	hm3	cx4	cx5
show or hide all annotated terms
behavior/neurological		√
head shaking		√
circling		√
growth/size/body					√
decreased body size					√
hearing/vestibular/ear	√	√	√	√	√
abnormal organ of Corti morphology		√			√
abnormal cochlear hair cell morphology		√
abnormal cochlear hair cell stereociliary bundle morphology					√
abnormal cochlear hair cell inter-stereocilial links morphology			√
abnormal inner hair cell stereociliary bundle morphology			√
short cochlear hair cell stereocilia					√
short inner hair cell stereocilia			√
short outer hair cell stereocilia	√
abnormal cochlear outer hair cell morphology	√
organ of Corti degeneration		√
abnormal stria vascularis morphology		√
abnormal tectorial membrane morphology		√
abnormal utricular macula morphology		√
increased susceptibility to age-related hearing loss				√
deafness		√
nervous system	√	√	√		√
abnormal cochlear hair cell morphology		√
abnormal cochlear hair cell stereociliary bundle morphology					√
abnormal cochlear hair cell inter-stereocilial links morphology			√
abnormal inner hair cell stereociliary bundle morphology			√
short cochlear hair cell stereocilia					√
short inner hair cell stereocilia			√
short outer hair cell stereocilia	√
abnormal cochlear outer hair cell morphology	√
abnormal cochlear ganglion morphology		√
cochlear ganglion degeneration		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Myo15a Mutation:	136 strains or lines available

Notes

The Myo15^sh2 mutation was discovered by Dobrovolskaia-Zavadskaia (J:15021) in descendants of an irradiated male.

References

Original:	J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
All:	37 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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