Noto<tc> Spontaneous Allele Detail MGI Mouse (MGI:1857063)

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Noto^tc
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Noto^tc
Name:	notochord homeobox; truncate
MGI ID:	MGI:1857063
Synonyms:	bo, boneless, boneless tail, jt, tc
Gene:	Noto Location: Chr6:85400868-85405859 bp, + strand Genetic Position: Chr6, 37.44 cM
Alliance:	Noto^tc page

Mutation
origin

Strain of Origin:

Swiss albino stock

Mutation
description

Allele Type:		Spontaneous (Hypomorph)
Mutation:		Single point mutation
		Mutation details: A T-to-G transversion causes a phenylalanine to cysteine substitution in position 168 ( amino-acid 20 of helix 1 of the homeodomain) (p.F168C). This allele is hypomorphic. (J:91405)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Noto Mutation:	15 strains or lines available

References

Original:	J:64444 Griffen A, tc - truncate. Mouse News Lett. 1951;5:31
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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