Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Rag1tm1Mom
Name:	recombination activating 1; targeted mutation 1, Peter Mombaerts
MGI ID:	MGI:1857241
Synonyms:	Rag-, Rag1-, RAG-1-, Rag-1KO, RAG1null, Rag1tm1Mom
Gene:	Rag1  Location: Chr2:101468627-101479846 bp, - strand  Genetic Position: Chr2, 53.88 cM
Alliance:	Rag1tm1Mom page

Germline Transmission:	Earliest citation of germline transmission: J:1934
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. (J:1934, J:96036)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	44 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

List all tumor models in MMHCdb carrying Rag1tm1Mom

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 49 strains available      Cell Lines: 0 lines available
Carrying any Rag1 Mutation:	123 strains or lines available

Original:	J:1934 Mombaerts P, et al., RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 1992 Mar 6;68(5):869-77
All:	1961 reference(s)