VcanTg(Hoxa1)1Chm
Transgenic Allele Detail
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| Symbol: |
VcanTg(Hoxa1)1Chm |
| Name: |
versican; transgene insertion 1, Corey H Mjaatvedt |
| MGI ID: |
MGI:1857689 |
| Synonyms: |
Cspg2hdf, hdf, hdf, heart defect, Vcanhdf |
| Gene: |
Vcan Location: Chr13:89803431-89890628 bp, - strand Genetic Position: Chr13, 45.5 cM
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| Alliance: |
VcanTg(Hoxa1)1Chm page
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| Strain of Origin: |
C57BL/6J or CBA
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| Transgene Type: |
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Transgenic (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene consisted of 3.5kb of the Hoxa1 regulatory region gene with a lacZ reporter sequence. The transgene inserted into intron 7 and separates exons 7 and 8, which code for the two chondroitin sulfate binding domains. RT-PCR analysis detected truncated mRNA transcripts in homozygous embryos. None of the alternative splice forms of the gene are detected in hearts from homozygous mice.
(J:50233)
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| Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Vcan Mutation: |
164 strains or lines available
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| Original: |
J:41016 Yamamura H, et al., A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev Biol. 1997 Jun 1;186(1):58-72 |
| All: |
16 reference(s) |
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Analysis Tools
