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Tomm40 Gene Detail
Summary
  • Symbol
    Tomm40
  • Name
    translocase of outer mitochondrial membrane 40
  • Synonyms
    Tom40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858259
    NCBI Gene: 53333
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19435238-19449363 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858259
 protein coding gene Chr7:19435238-19449370 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031793
 protein coding gene Chr7:17741171-17757582 (-)
A/J MGP_AJ_G0031769
 protein coding gene Chr7:17350986-17364761 (-)
AKR/J MGP_AKRJ_G0031695
 protein coding gene Chr7:17835414-17849467 (-)
BALB/cJ MGP_BALBcJ_G0031774
 protein coding gene Chr7:17556575-17571285 (-)
C3H/HeJ MGP_C3HHeJ_G0031496
 protein coding gene Chr7:18097122-18112284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032240
 protein coding gene Chr7:18616644-18634985 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029306
 protein coding gene Chr7:19000367-19013790 (-)
CAST/EiJ MGP_CASTEiJ_G0030839
 protein coding gene Chr7:14535376-14558648 (-)
CBA/J MGP_CBAJ_G0031458
 protein coding gene Chr7:19293072-19307390 (-)
DBA/2J MGP_DBA2J_G0031613
 protein coding gene Chr7:17304820-17320055 (-)
FVB/NJ MGP_FVBNJ_G0031565
 protein coding gene Chr7:17173283-17187074 (-)
LP/J MGP_LPJ_G0031696
 protein coding gene Chr7:18052723-18069893 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031601
 protein coding gene Chr7:19113807-19128445 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032268
 protein coding gene Chr7:17445865-17462976 (-)
PWK/PhJ MGP_PWKPhJ_G0030563
 protein coding gene Chr7:14404835-14419554 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030390
 protein coding gene Chr7:12150268-12168576 (-)
WSB/EiJ MGP_WSBEiJ_G0030939
 protein coding gene Chr7:17662547-17678702 (-)



Homology
more
  • Human Ortholog
    TOMM40, translocase of outer mitochondrial membrane 40
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOMM40, translocase of outer mitochondrial membrane 40
  • Synonyms
    C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40
  • Links
    NCBI Gene ID: 10452
    neXtProt AC: NX_O96008
    UniProt: O96008

  • Chr Location
    19q13.32; chr19:44890569-44903689 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TOMM40 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002984 Ensembl Gene Model | MGI Sequence Detail 14126 C57BL/6J ±  kb
    transcript ENSMUST00000093552 Ensembl | MGI Sequence Detail 1577 Not Applicable  
    polypeptide ENSMUSP00000104090 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142249
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory