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Gal3st1 Gene Detail
Summary
  • Symbol
    Gal3st1
  • Name
    galactose-3-O-sulfotransferase 1
  • Synonyms
    3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase, Cst, galactosylceramide sulfotransferase, GalCer sulfotransferase, Gcst
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858277
    NCBI Gene: 53897
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3933636-3949326 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.81 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858277
 protein coding gene Chr11:3933636-3949328 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017970
 protein coding gene Chr11:895429-911757 (+)
A/J MGP_AJ_G0017943
 protein coding gene Chr11:916171-931572 (+)
AKR/J MGP_AKRJ_G0017907
 protein coding gene Chr11:964677-979887 (+)
BALB/cJ MGP_BALBcJ_G0017911
 protein coding gene Chr11:885975-901403 (+)
C3H/HeJ MGP_C3HHeJ_G0017724
 protein coding gene Chr11:877996-893233 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018364
 protein coding gene Chr11:979734-995515 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016022
 protein coding gene Chr11:802812-819663 (+)
CAST/EiJ MGP_CASTEiJ_G0017286
 protein coding gene Chr11:838360-854661 (+)
CBA/J MGP_CBAJ_G0017699
 protein coding gene Chr11:1192445-1215556 (+)
DBA/2J MGP_DBA2J_G0017810
 protein coding gene Chr11:822100-837531 (+)
FVB/NJ MGP_FVBNJ_G0017801
 protein coding gene Chr11:859450-875319 (+)
LP/J MGP_LPJ_G0017880
 protein coding gene Chr11:992725-1008138 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017827
 protein coding gene Chr11:897240-912714 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018403
 protein coding gene Chr11:958543-978456 (+)
PWK/PhJ MGP_PWKPhJ_G0017067
 protein coding gene Chr11:819301-834932 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016863
 protein coding gene Chr11:924483-939822 (+)
WSB/EiJ MGP_WSBEiJ_G0017340
 protein coding gene Chr11:850075-865494 (+)



Homology
more
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAL3ST1, galactose-3-O-sulfotransferase 1
  • Synonyms
    CST
  • Links
    NCBI Gene ID: 9514
    neXtProt AC: NX_Q99999
    UniProt: Q99999

  • Chr Location
    22q12.2; chr22:30554635-30574665 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hindlimb weakness and progressive ataxia beginning at six weeks of age. Homozygous males exhibit sterility with a block in spermatogenesis prior to the first meiotic division.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    111
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049721 Ensembl Gene Model | MGI Sequence Detail 15691 C57BL/6J ±  kb
    transcript ENSMUST00000109981 Ensembl | MGI Sequence Detail 1600 Not Applicable  
    polypeptide ENSMUSP00000105608 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:289085 Honke K, et al., Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. J Biol Chem. 1997 Feb 21;272(8):4864-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory