Myo5a<flr> Spontaneous Allele Detail MGI Mouse (MGI:1858520)

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Myo5a^flr
Spontaneous Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Myo5a^flr
Name:	myosin VA; flailer
MGI ID:	MGI:1858520
Synonyms:	flail, flr, tb^2J
Gene:	Myo5a Location: Chr9:74978297-75130970 bp, + strand Genetic Position: Chr9, 42.26 cM
Alliance:	Myo5a^flr page

Mutation
origin

Strain of Origin:

C57BL/10J

Mutation
description

Allele Type:		Spontaneous
Mutation:		Other
		Mutation details: Hybrid. This mutation is caused by gene shuffling between Gnb5 and Myo5a. The shuffling combines the promoter of the first two exons of Gnb5 with the C-terminal exons of Myo5a. Flailer homozygotes express transcripts of three genes: wild-type Gnb5, wild-type Myo5a and the flailer hybrid gene. (J:61324)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Myo5a Mutation:	265 strains or lines available

References

Original:	J:79827 The Jackson Laboratory Office of Genetic Resources, Registry of Remutation at The Jackson Laboratory. MGI Direct Data Submission. 1973;
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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