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Egfl6 Gene Detail
Summary
  • Symbol
    Egfl6
  • Name
    EGF-like-domain, multiple 6
  • Synonyms
    Maeg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858599
    NCBI Gene: 54156
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:165306003-165368712 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 77.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1553 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858599
 protein coding gene ChrX:165306003-165368716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036268
 protein coding gene ChrX:164654524-164720460 (-)
A/J MGP_AJ_G0036237
 protein coding gene ChrX:163807197-163870489 (-)
AKR/J MGP_AKRJ_G0036167
 protein coding gene ChrX:169064006-169133884 (-)
BALB/cJ MGP_BALBcJ_G0036232
 protein coding gene ChrX:161794202-161857553 (-)
C3H/HeJ MGP_C3HHeJ_G0035939
 protein coding gene ChrX:164970150-165033618 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036755
 protein coding gene ChrX:169451212-169526598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033575
 protein coding gene ChrX:154666868-154727347 (-)
CAST/EiJ MGP_CASTEiJ_G0035226
 protein coding gene ChrX:143859971-143926491 (-)
CBA/J MGP_CBAJ_G0035913
 protein coding gene ChrX:174399329-174470231 (-)
DBA/2J MGP_DBA2J_G0036079
 protein coding gene ChrX:162634732-162697263 (-)
FVB/NJ MGP_FVBNJ_G0036011
 protein coding gene ChrX:161759334-161826888 (-)
LP/J MGP_LPJ_G0036164
 protein coding gene ChrX:165780444-165843940 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036043
 protein coding gene ChrX:183110257-183175226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036794
 protein coding gene ChrX:164140826-164204978 (-)
PWK/PhJ MGP_PWKPhJ_G0034925
 protein coding gene ChrX:140603123-140671317 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034744
 protein coding gene ChrX:144382039-144459176 (-)
WSB/EiJ MGP_WSBEiJ_G0035362
 protein coding gene ChrX:161974880-162043723 (-)



Homology
more
  • Human Ortholog
    EGFL6, EGF like domain multiple 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGFL6, EGF like domain multiple 6
  • Synonyms
    MAEG, W80
  • Links
    NCBI Gene ID: 25975
    neXtProt AC: NX_Q8IUX8
    UniProt: Q8IUX8

  • Chr Location
    Xp22.2; chrX:13569601-13633575 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Mice hemizygous for a targeted allele are apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    875
  • Tissues
    76
  • cDNA Data
    9
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54156 NCBI Gene Model | MGI Sequence Detail 62710 C57BL/6J ±  kb
transcript NM_019397 RefSeq | MGI Sequence Detail 2700 ZRU/MplStud  
polypeptide Q9JJZ5 UniProt | EBI | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 9
    Primer pair 2
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 13
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:61762 Buchner G, et al., Identification of a new EGF-repeat-containing gene from human Xp22: a candidate for developmental disorders. Genomics. 2000 Apr 1;65(1):16-23
  • Latest
    J:333737 Wilson CL, et al., Nephronectin is required to maintain right lung lobar separation during embryonic development. Am J Physiol Lung Cell Mol Physiol. 2023 Jan 31;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory