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Vamp4 Gene Detail
Summary
  • Symbol
    Vamp4
  • Name
    vesicle-associated membrane protein 4
  • Synonyms
    D1Ertd147e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858730
    NCBI Gene: 53330
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:162398084-162426651 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 70.29 cM, cytoband H1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    871 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858730
 protein coding gene Chr1:162398084-162426653 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016660
 protein coding gene Chr1:167906785-167935575 (+)
A/J MGP_AJ_G0016641
 protein coding gene Chr1:161071132-161099987 (+)
AKR/J MGP_AKRJ_G0016607
 protein coding gene Chr1:165952993-165984150 (+)
BALB/cJ MGP_BALBcJ_G0016602
 protein coding gene Chr1:161601659-161631088 (+)
C3H/HeJ MGP_C3HHeJ_G0016426
 protein coding gene Chr1:166164399-166192783 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017063
 protein coding gene Chr1:173563960-173594715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014772
 protein coding gene Chr1:153128104-153158653 (+)
CAST/EiJ MGP_CASTEiJ_G0016006
 protein coding gene Chr1:165814041-165844004 (+)
CBA/J MGP_CBAJ_G0016401
 protein coding gene Chr1:179743121-179774486 (+)
DBA/2J MGP_DBA2J_G0016507
 protein coding gene Chr1:160018792-160047611 (+)
FVB/NJ MGP_FVBNJ_G0016505
 protein coding gene Chr1:158445700-158474081 (+)
LP/J MGP_LPJ_G0016578
 protein coding gene Chr1:169033391-169063910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016530
 protein coding gene Chr1:187258038-187287370 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017099
 protein coding gene Chr1:165789142-165818454 (+)
PWK/PhJ MGP_PWKPhJ_G0015792
 protein coding gene Chr1:159193636-159222762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015579
 protein coding gene Chr1:164678124-164699340 (+)
WSB/EiJ MGP_WSBEiJ_G0016068
 protein coding gene Chr1:165971965-166000332 (+)



Homology
more
  • Human Ortholog
    VAMP4, vesicle associated membrane protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAMP4, vesicle associated membrane protein 4
  • Synonyms
    VAMP24, VAMP-4
  • Links
    NCBI Gene ID: 8674
    neXtProt AC: NX_O75379
    UniProt: O75379

  • Chr Location
    1q24.3; chr1:171700160-171742074 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased insulin in pancreas beta cells and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53330 NCBI Gene Model | MGI Sequence Detail 28568 C57BL/6J ±  kb
    transcript NM_001356527 RefSeq | MGI Sequence Detail 5253 ZRU/MplStud  
    polypeptide O70480 UniProt | EBI | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1098701
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory