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Akap7 Gene Detail
Summary
  • Symbol
    Akap7
  • Name
    A kinase anchor protein 7
  • Synonyms
    AKAP15, Akap18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859150
    NCBI Gene: 432442
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:25044988-25175115 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 12.26 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4635 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859150
 protein coding gene Chr10:25044988-25183768 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017097
 protein coding gene Chr10:23186112-23331402 (-)
A/J MGP_AJ_G0017074
 protein coding gene Chr10:22493259-22632343 (-)
AKR/J MGP_AKRJ_G0017034
 protein coding gene Chr10:22875303-23015442 (-)
BALB/cJ MGP_BALBcJ_G0017037
 protein coding gene Chr10:22599961-22738890 (-)
C3H/HeJ MGP_C3HHeJ_G0016857
 protein coding gene Chr10:23084043-23226826 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017495
 protein coding gene Chr10:23908992-24056591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015193
 protein coding gene Chr10:21176180-21308426 (-)
CAST/EiJ MGP_CASTEiJ_G0016436
 protein coding gene Chr10:23030674-23183779 (-)
CBA/J MGP_CBAJ_G0016831
 protein coding gene Chr10:25007458-25161410 (-)
DBA/2J MGP_DBA2J_G0016936
 protein coding gene Chr10:22219802-22358413 (-)
FVB/NJ MGP_FVBNJ_G0016931
 protein coding gene Chr10:21925326-22063098 (-)
LP/J MGP_LPJ_G0017013
 protein coding gene Chr10:23167674-23314451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016961
 protein coding gene Chr10:25074182-25225019 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017531
 protein coding gene Chr10:22731892-22877311 (-)
PWK/PhJ MGP_PWKPhJ_G0016218
 protein coding gene Chr10:22017881-22160959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016002
 protein coding gene Chr10:22556592-22705845 (-)
WSB/EiJ MGP_WSBEiJ_G0016499
 protein coding gene Chr10:22864283-23007665 (-)



Homology
more
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP7, A-kinase anchoring protein 7
  • Synonyms
    AKAP15, AKAP18
  • Links
    NCBI Gene ID: 9465
    neXtProt AC: NX_O43687, NX_Q9P0M2
    UniProt: O43687, Q9P0M2

  • Chr Location
    6q23.2; chr6:131125627-131283535 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and show normal cardiomyocyte response to adrenergic stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    20
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 432442 NCBI Gene Model | MGI Sequence Detail 130128 C57BL/6J ±  kb
    transcript NR_166567 RefSeq | MGI Sequence Detail 4143 C57BL/6  
    polypeptide Q7TN79 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000004556 A-kinase anchor protein 7
      (term hierarchy)
    • InterPro Domains
      IPR052641 A-kinase anchor protein 7 isoform gamma
      IPR019510 A-kinase anchor protein 7-like, phosphoesterase domain
      IPR019511 A-kinase anchor protein 7, RI-RII subunit-binding domain
      IPR009097 Cyclic phosphodiesterase
    • GlyGen
      Q7TN79 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143664, MGI:2143901
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory