About   Help   FAQ
Cacng4 Gene Detail
Summary
  • Symbol
    Cacng4
  • Name
    calcium channel, voltage-dependent, gamma subunit 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859167
    NCBI Gene: 54377
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:107623183-107685383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.29 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1777 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859167
 protein coding gene Chr11:107623183-107685532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019323
 protein coding gene Chr11:111154083-111218928 (-)
A/J MGP_AJ_G0019291
 protein coding gene Chr11:106386079-106448619 (-)
AKR/J MGP_AKRJ_G0019260
 protein coding gene Chr11:109565611-109631398 (-)
BALB/cJ MGP_BALBcJ_G0019265
 protein coding gene Chr11:106805046-106871944 (-)
C3H/HeJ MGP_C3HHeJ_G0019074
 protein coding gene Chr11:109878472-109943846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019715
 protein coding gene Chr11:114582939-114647789 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017339
 protein coding gene Chr11:103647309-103708568 (-)
CAST/EiJ MGP_CASTEiJ_G0018627
 protein coding gene Chr11:110979784-111045429 (-)
CBA/J MGP_CBAJ_G0019043
 protein coding gene Chr11:119316403-119380821 (-)
DBA/2J MGP_DBA2J_G0019155
 protein coding gene Chr11:105862294-105929939 (-)
FVB/NJ MGP_FVBNJ_G0019146
 protein coding gene Chr11:105369842-105431919 (-)
LP/J MGP_LPJ_G0019225
 protein coding gene Chr11:111597548-111666076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019176
 protein coding gene Chr11:118531072-118597206 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019752
 protein coding gene Chr11:110116850-110189292 (-)
PWK/PhJ MGP_PWKPhJ_G0018392
 protein coding gene Chr11:107008976-107071951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018183
 protein coding gene Chr11:109883608-109945636 (-)
WSB/EiJ MGP_WSBEiJ_G0018678
 protein coding gene Chr11:110066219-110131495 (-)



Homology
more
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNG4, calcium voltage-gated channel auxiliary subunit gamma 4
  • Links
    NCBI Gene ID: 27092
    neXtProt AC: NX_Q9UBN1
    UniProt: Q9UBN1

  • Chr Location
    17q24.2; chr17:66964707-67033398 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable, fertile and phenotypically normal with no ataxic gait or absence seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1052
  • Tissues
    124
  • cDNA Data
    6
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020723 Ensembl Gene Model | MGI Sequence Detail 62201 C57BL/6J ±  kb
transcript ENSMUST00000021066 Ensembl | MGI Sequence Detail 3500 Not Applicable  
polypeptide ENSMUSP00000021066 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004953 voltage-dependent calcium channel gamma-4 subunit
    (term hierarchy)
  • InterPro Domains
    IPR004031 PMP-22/EMP/MP20/Claudin
    IPR005423 Voltage-dependent calcium channel, gamma-4 subunit
    IPR051072 Voltage-dependent calcium channel gamma subunit
    IPR008368 Voltage-dependent calcium channel, gamma subunit
  • GlyGen
    Q9JJV4 2 sites
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 7
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144142, MGI:2144541
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 8
  • Earliest
    J:61749 Burgess DL, et al., Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. Genome Res. 1999 Dec;9(12):1204-13
  • Latest
    J:278108 Luan C, et al., The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification. Commun Biol. 2019;2:106
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory