About   Help   FAQ
Cldn7 Gene Detail
Summary
  • Symbol
    Cldn7
  • Name
    claudin 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859285
    NCBI Gene: 53624
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69855605-69858711 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.94 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859285
 protein coding gene Chr11:69855605-69858712 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018572
 protein coding gene Chr11:70454654-70457719 (+)
A/J MGP_AJ_G0018540
 protein coding gene Chr11:67789360-67792425 (+)
AKR/J MGP_AKRJ_G0018509
 protein coding gene Chr11:69809673-69812738 (+)
BALB/cJ MGP_BALBcJ_G0018512
 protein coding gene Chr11:68118463-68121528 (+)
C3H/HeJ MGP_C3HHeJ_G0018325
 protein coding gene Chr11:69847931-69852548 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018963
 protein coding gene Chr11:72580539-72583604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016608
 protein coding gene Chr11:64714690-64717800 (+)
CAST/EiJ MGP_CASTEiJ_G0017880
 protein coding gene Chr11:70091864-70094931 (+)
CBA/J MGP_CBAJ_G0018297
 protein coding gene Chr11:75835253-75838318 (+)
DBA/2J MGP_DBA2J_G0018407
 protein coding gene Chr11:67372206-67375272 (+)
FVB/NJ MGP_FVBNJ_G0018397
 protein coding gene Chr11:67021146-67024211 (+)
LP/J MGP_LPJ_G0018477
 protein coding gene Chr11:71039457-71042522 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018420
 protein coding gene Chr11:76426224-76429289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019005
 protein coding gene Chr11:70083316-70086381 (+)
PWK/PhJ MGP_PWKPhJ_G0017654
 protein coding gene Chr11:68025407-68028473 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017444
 protein coding gene Chr11:69901966-69905030 (+)
WSB/EiJ MGP_WSBEiJ_G0017934
 protein coding gene Chr11:69747191-69750256 (+)



Homology
more
  • Human Ortholog
    CLDN7, claudin 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN7, claudin 7
  • Synonyms
    CEPTRL2, claudin-1, CLDN-7, CPETRL2, Hs.84359
  • Links
    NCBI Gene ID: 1366
    neXtProt AC: NX_O95471
    UniProt: O95471

  • Chr Location
    17p13.1; chr17:7259903-7263983 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body size, weight, and length; abnormal potassium, chloride, and sodium ion excretion; chronic dehydration; and postnatal lethality by P12.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    54
  • cDNA Data
    170
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018569 Ensembl Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
    transcript ENSMUST00000108597 Ensembl | MGI Sequence Detail 913 Not Applicable  
    polypeptide ENSMUSP00000104238 Ensembl | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 170
      Primer pair 6
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 32
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:337005 Ozekin YH, et al., Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity. Dev Dyn. 2023 Jun;252(6):713-727
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory