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Cldn8 Gene Detail
Summary
  • Symbol
    Cldn8
  • Name
    claudin 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859286
    NCBI Gene: 54420
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:88357716-88360071 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859286
 protein coding gene Chr16:88357714-88360071 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022984
 protein coding gene Chr16:89364730-89367083 (-)
A/J MGP_AJ_G0022952
 protein coding gene Chr16:85220370-85222725 (-)
AKR/J MGP_AKRJ_G0022922
 protein coding gene Chr16:87805689-87808044 (-)
BALB/cJ MGP_BALBcJ_G0022954
 protein coding gene Chr16:85750642-85752997 (-)
C3H/HeJ MGP_C3HHeJ_G0022716
 protein coding gene Chr16:88373228-88375583 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023401
 protein coding gene Chr16:92238457-92240812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020905
 protein coding gene Chr16:83053430-83055770 (-)
CAST/EiJ MGP_CASTEiJ_G0022238
 protein coding gene Chr16:88805664-88808012 (-)
CBA/J MGP_CBAJ_G0022685
 protein coding gene Chr16:96192392-96194747 (-)
DBA/2J MGP_DBA2J_G0022819
 protein coding gene Chr16:85145143-85147498 (-)
FVB/NJ MGP_FVBNJ_G0022794
 protein coding gene Chr16:84248911-84251266 (-)
LP/J MGP_LPJ_G0022888
 protein coding gene Chr16:89049516-89051869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022813
 protein coding gene Chr16:100722558-100724913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023419
 protein coding gene Chr16:88313620-88315974 (-)
PWK/PhJ MGP_PWKPhJ_G0021981
 protein coding gene Chr16:85299967-85302328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021811
 protein coding gene Chr16:87867145-87869504 (-)
WSB/EiJ MGP_WSBEiJ_G0022286
 protein coding gene Chr16:88535161-88537516 (-)



Homology
more
  • Human Ortholog
    CLDN8, claudin 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN8, claudin 8
  • Synonyms
    HEL-S-79
  • Links
    NCBI Gene ID: 9073
    neXtProt AC: NX_P56748
    UniProt: P56748

  • Chr Location
    21q22.11; chr21:30214006-30216097 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1087
  • Tissues
    256
  • cDNA Data
    48
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050520 Ensembl Gene Model | MGI Sequence Detail 2356 C57BL/6J ±  kb
    transcript ENSMUST00000049697 Ensembl | MGI Sequence Detail 2356 Not Applicable  
    polypeptide ENSMUSP00000051887 Ensembl | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 48
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146473
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 19
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory