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Atp11c Gene Detail
Summary
  • Symbol
    Atp11c
  • Name
    ATPase, class VI, type 11C
  • Synonyms
    A330005H02Rik, Ig
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859661
    NCBI Gene: 320940
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:59268643-59450041 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 33.50 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859661
 protein coding gene ChrX:59268643-59636304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035757
 protein coding gene ChrX:55585958-55970741 (-)
A/J MGP_AJ_G0035739
 protein coding gene ChrX:55782599-56163382 (-)
AKR/J MGP_AKRJ_G0035659
 protein coding gene ChrX:57297156-57679205 (-)
BALB/cJ MGP_BALBcJ_G0035726
 protein coding gene ChrX:55147085-55531443 (-)
C3H/HeJ MGP_C3HHeJ_G0035428
 protein coding gene ChrX:56134954-56516756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036255
 protein coding gene ChrX:57077101-57486592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033107
 protein coding gene ChrX:55605163-55962826 (-)
CAST/EiJ MGP_CASTEiJ_G0034721
 protein coding gene ChrX:41898834-42276240 (-)
CBA/J MGP_CBAJ_G0035403
 protein coding gene ChrX:58768954-59180890 (-)
DBA/2J MGP_DBA2J_G0035557
 protein coding gene ChrX:55353563-55737213 (-)
FVB/NJ MGP_FVBNJ_G0035507
 protein coding gene ChrX:54904663-55275854 (-)
LP/J MGP_LPJ_G0035645
 protein coding gene ChrX:56173571-56551235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035543
 protein coding gene ChrX:60334611-60739521 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036271
 protein coding gene ChrX:55628015-56007997 (-)
PWK/PhJ MGP_PWKPhJ_G0034416
 protein coding gene ChrX:40080136-40466105 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034261
 protein coding gene ChrX:42743075-43132375 (-)
WSB/EiJ MGP_WSBEiJ_G0034864
 protein coding gene ChrX:55094607-55482112 (-)



Homology
more
  • Human Ortholog
    ATP11C, ATPase phospholipid transporting 11C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP11C, ATPase phospholipid transporting 11C
  • Synonyms
    ATPIG, ATPIQ, HACXL
  • Links
    NCBI Gene ID: 286410
    neXtProt AC: NX_Q8NB49
    UniProt: Q8NB49

  • Chr Location
    Xq27.1; chrX:139726346-139945276 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP11C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    7 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or hemizygous for an ENU mutation exhibit decreased B cells associated with arrested adult B cell lymphopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    4
  • cDNA Data
    18
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320940 NCBI Gene Model | MGI Sequence Detail 181399 C57BL/6J ±  kb
    transcript NM_001037863 RefSeq | MGI Sequence Detail 6096 C57BL/6  
    polypeptide Q9QZW0 UniProt | EBI | MGI Sequence Detail 1129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147864, MGI:2445086
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
    • Latest
      J:349093 Dearden L, et al., Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. PLoS Biol. 2024 Jun;22(6):e3002641
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory