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Cdc20 Gene Detail
Summary
  • Symbol
    Cdc20
  • Name
    cell division cycle 20
  • Synonyms
    2310042N09Rik, p55CDC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859866
    NCBI Gene: 107995
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118290098-118294540 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859866
 protein coding gene Chr4:118290098-118294549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028668
 protein coding gene Chr4:119489836-119494287 (-)
A/J MGP_AJ_G0028629
 protein coding gene Chr4:114854808-114859270 (-)
AKR/J MGP_AKRJ_G0028579
 protein coding gene Chr4:117359270-117363721 (-)
BALB/cJ MGP_BALBcJ_G0028650
 protein coding gene Chr4:115495757-115500222 (-)
C3H/HeJ MGP_C3HHeJ_G0028364
 protein coding gene Chr4:118938456-118942921 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029091
 protein coding gene Chr4:124054408-124058859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026375
 protein coding gene Chr4:108873907-108878374 (-)
CAST/EiJ MGP_CASTEiJ_G0027798
 protein coding gene Chr4:116197584-116202047 (-)
CBA/J MGP_CBAJ_G0028331
 protein coding gene Chr4:127462194-127466659 (-)
DBA/2J MGP_DBA2J_G0028479
 protein coding gene Chr4:115465777-115470239 (-)
FVB/NJ MGP_FVBNJ_G0028447
 protein coding gene Chr4:113984881-113989346 (-)
LP/J MGP_LPJ_G0028581
 protein coding gene Chr4:119670124-119674575 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028474
 protein coding gene Chr4:132342541-132347006 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029128
 protein coding gene Chr4:118523856-118528313 (-)
PWK/PhJ MGP_PWKPhJ_G0027524
 protein coding gene Chr4:112297989-112302526 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027347
 protein coding gene Chr4:114824470-114828915 (-)
WSB/EiJ MGP_WSBEiJ_G0027877
 protein coding gene Chr4:118419976-118427173 (-)



Homology
more
  • Human Ortholog
    CDC20, cell division cycle 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC20, cell division cycle 20
  • Synonyms
    bA276H19.3, CDC20A, OOMD14, OZEMA14, p55CDC
  • Links
    NCBI Gene ID: 991
    neXtProt AC: NX_Q12834
    UniProt: Q12834

  • Chr Location
    1p34.2; chr1:43358981-43363203 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 6 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display embryonic lethality with cell cycle abnormalities. Mice heterozygous for a mutation in this gene display increased tumor incidence and increased incidence of aneuploidy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    40
  • cDNA Data
    13
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107995 NCBI Gene Model | MGI Sequence Detail 4443 C57BL/6J ±  kb
    transcript NM_023223 RefSeq | MGI Sequence Detail 1793 C57BL/6  
    polypeptide Q9JJ66 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1913810, MGI:2146726
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 32
      Gene Ontology 20
      Phenotypes 34
    • Earliest
      J:59059 Inbal N, et al., The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 1999 Dec 17;463(3):350-4
    • Latest
      J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory