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Panx1 Gene Detail
Summary
  • Symbol
    Panx1
  • Name
    pannexin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860055
    NCBI Gene: 55991
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14917081-14956774 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860055
 protein coding gene Chr9:14913424-14956774 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034359
 protein coding gene Chr9:11967632-12010611 (-)
A/J MGP_AJ_G0034337
 protein coding gene Chr9:11906021-11950130 (-)
AKR/J MGP_AKRJ_G0034265
 protein coding gene Chr9:11921666-11961629 (-)
BALB/cJ MGP_BALBcJ_G0034331
 protein coding gene Chr9:11684781-11725133 (-)
C3H/HeJ MGP_C3HHeJ_G0034042
 protein coding gene Chr9:12228279-12274479 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034853
 protein coding gene Chr9:12362857-12406021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031791
 protein coding gene Chr9:11207736-11245635 (-)
CAST/EiJ MGP_CASTEiJ_G0033369
 protein coding gene Chr9:12058430-12118373 (-)
CBA/J MGP_CBAJ_G0034015
 protein coding gene Chr9:12933045-12984224 (-)
DBA/2J MGP_DBA2J_G0034172
 protein coding gene Chr9:11785847-11825112 (-)
FVB/NJ MGP_FVBNJ_G0034117
 protein coding gene Chr9:11375735-11412618 (-)
LP/J MGP_LPJ_G0034258
 protein coding gene Chr9:12071942-12118600 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034161
 protein coding gene Chr9:13953286-14010984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034872
 protein coding gene Chr9:11942418-11985864 (-)
PWK/PhJ MGP_PWKPhJ_G0033075
 protein coding gene Chr9:11839135-11899097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032911
 protein coding gene Chr9:12038204-12086209 (-)
WSB/EiJ MGP_WSBEiJ_G0033485
 protein coding gene Chr9:11797027-11842277 (-)



Homology
more
  • Human Ortholog
    PANX1, pannexin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PANX1, pannexin 1
  • Synonyms
    MRS1, OOMD7, OZEMA7, PX1, UNQ2529
  • Links
    NCBI Gene ID: 24145
    neXtProt AC: NX_Q96RD7
    UniProt: Q96RD7

  • Chr Location
    11q21; chr11:94128841-94181968 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PANX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    127 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired macrophage recruitment, YO-PRO-1 dye uptake, ATP release by apoptotic thymocytes, hippocampal neurons, and astrocytes. Mice homozygous for a different knock-out allele exhibit protection from I/R-induced retinal ganglion cell loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    114
  • cDNA Data
    54
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 55991 NCBI Gene Model | MGI Sequence Detail 39694 C57BL/6J ±  kb
    transcript NM_019482 RefSeq | MGI Sequence Detail 2112 C57BL/6  
    polypeptide Q9JIP4 UniProt | EBI | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 54
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143143
    References
    more
    • Summaries
      All 197
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 127
    • Earliest
      J:62853 Panchin Y, et al., A ubiquitous family of putative gap junction molecules. Curr Biol. 2000 Jun 29;10(13):R473-4
    • Latest
      J:354844 Vardam-Kaur T, et al., The ATP-exporting channel Pannexin 1 promotes CD8(+) T cell effector and memory responses. iScience. 2024 Jul 19;27(7):110290
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory