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Ubr3 Gene Detail
Summary
  • Symbol
    Ubr3
  • Name
    ubiquitin protein ligase E3 component n-recognin 3
  • Synonyms
    1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861100
    NCBI Gene: 68795
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69727590-69854357 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 40.95 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2980 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861100
 protein coding gene Chr2:69727276-69854357 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025809
 protein coding gene Chr2:69899842-70032868 (+)
A/J MGP_AJ_G0025786
 protein coding gene Chr2:67200018-67330115 (+)
AKR/J MGP_AKRJ_G0025755
 protein coding gene Chr2:69021827-69152459 (+)
BALB/cJ MGP_BALBcJ_G0025781
 protein coding gene Chr2:67360910-67488918 (+)
C3H/HeJ MGP_C3HHeJ_G0025541
 protein coding gene Chr2:69252952-69384147 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026228
 protein coding gene Chr2:72013354-72150399 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023631
 protein coding gene Chr2:64425493-64558411 (+)
CAST/EiJ MGP_CASTEiJ_G0025005
 protein coding gene Chr2:69366772-69511150 (+)
CBA/J MGP_CBAJ_G0025521
 protein coding gene Chr2:74672008-74816673 (+)
DBA/2J MGP_DBA2J_G0025652
 protein coding gene Chr2:66832599-66961864 (+)
FVB/NJ MGP_FVBNJ_G0025615
 protein coding gene Chr2:66214475-66341211 (+)
LP/J MGP_LPJ_G0025741
 protein coding gene Chr2:69757954-69892821 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025644
 protein coding gene Chr2:76729033-76876705 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026285
 protein coding gene Chr2:69107397-69246661 (+)
PWK/PhJ MGP_PWKPhJ_G0024746
 protein coding gene Chr2:66684866-66811853 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024553
 protein coding gene Chr2:69339044-69483407 (+)
WSB/EiJ MGP_WSBEiJ_G0025073
 protein coding gene Chr2:69536209-69670601 (+)



Homology
more
  • Human Ortholog
    UBR3, ubiquitin protein ligase E3 component n-recognin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBR3, ubiquitin protein ligase E3 component n-recognin 3
  • Synonyms
    ZNF650
  • Links
    NCBI Gene ID: 130507
    neXtProt AC: NX_Q6ZT12
    UniProt: Q6ZT12

  • Chr Location
    2q31.1; chr2:169827454-170084131 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    7
  • cDNA Data
    33
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044308 Ensembl Gene Model | MGI Sequence Detail 126768 C57BL/6J ±  kb
    transcript ENSMUST00000055758 Ensembl | MGI Sequence Detail 8072 Not Applicable  
    polypeptide ENSMUSP00000060159 Ensembl | MGI Sequence Detail 1889 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1916045, MGI:1921167, MGI:2138772, MGI:2138774, MGI:2139027, MGI:2139158, MGI:3035300, MGI:3045343
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:291759 Reichmann J, et al., Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes. J Cell Biol. 2020 May 4;219(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory