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Fzd2 Gene Detail
Summary
  • Symbol
    Fzd2
  • Name
    frizzled class receptor 2
  • Synonyms
    Fz10, Mfz10, Mfz10a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888513
    NCBI Gene: 57265
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102495257-102498884 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888513
 protein coding gene Chr11:102495222-102498884 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019240
 protein coding gene Chr11:105604257-105607938 (+)
A/J MGP_AJ_G0019208
 protein coding gene Chr11:101140322-101143991 (+)
AKR/J MGP_AKRJ_G0019177
 protein coding gene Chr11:104264535-104270032 (+)
BALB/cJ MGP_BALBcJ_G0019182
 protein coding gene Chr11:101620603-101624284 (+)
C3H/HeJ MGP_C3HHeJ_G0018991
 protein coding gene Chr11:104475081-104478762 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019631
 protein coding gene Chr11:108890163-108893825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017257
 protein coding gene Chr11:98564766-98568415 (+)
CAST/EiJ MGP_CASTEiJ_G0018545
 protein coding gene Chr11:105465646-105471307 (+)
CBA/J MGP_CBAJ_G0018960
 protein coding gene Chr11:113385615-113389277 (+)
DBA/2J MGP_DBA2J_G0019072
 protein coding gene Chr11:100650830-100654511 (+)
FVB/NJ MGP_FVBNJ_G0019062
 protein coding gene Chr11:100196198-100199860 (+)
LP/J MGP_LPJ_G0019141
 protein coding gene Chr11:106127072-106130753 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019093
 protein coding gene Chr11:112865847-112869516 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019669
 protein coding gene Chr11:104632196-104635865 (+)
PWK/PhJ MGP_PWKPhJ_G0018308
 protein coding gene Chr11:101717576-101721250 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018100
 protein coding gene Chr11:104389727-104394044 (+)
WSB/EiJ MGP_WSBEiJ_G0018594
 protein coding gene Chr11:104633963-104637625 (+)



Homology
more
  • Human Ortholog
    FZD2, frizzled class receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD2, frizzled class receptor 2
  • Synonyms
    fz-2, Fz2, fzE2, hFz2, OMOD2
  • Links
    NCBI Gene ID: 2535
    neXtProt AC: NX_Q14332
    UniProt: Q14332

  • Chr Location
    17q21.31; chr17:44557484-44561262 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FZD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    27 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 50% of mice homozygous for a reporter allele display a cleft palate and die as neonates; the remaining 50% survive exhibiting a variable degree of postnatal runting and reduced olfactory sensitivity to various odorants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1378
  • Tissues
    384
  • cDNA Data
    17
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57265 NCBI Gene Model | MGI Sequence Detail 3628 C57BL/6J ±  kb
    transcript NM_020510 RefSeq | MGI Sequence Detail 3628 C57BL/6  
    polypeptide Q9JIP6 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 18
      Primer pair 16
      Other 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144531
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 65
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory