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Pf4 Gene Detail
Summary
  • Symbol
    Pf4
  • Name
    platelet factor 4
  • Synonyms
    Cxcl4, Pf4, Scyb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888711
    NCBI Gene: 56744
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90920362-90921242 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888711
 protein coding gene Chr5:90920294-90921242 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029728
 protein coding gene Chr5:91863337-91864285 (+)
A/J MGP_AJ_G0029694
 protein coding gene Chr5:88237092-88238040 (+)
AKR/J MGP_AKRJ_G0029640
 protein coding gene Chr5:91099386-91100334 (+)
BALB/cJ MGP_BALBcJ_G0029704
 protein coding gene Chr5:89138048-89138996 (+)
C3H/HeJ MGP_C3HHeJ_G0029427
 protein coding gene Chr5:91518017-91518965 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030158
 protein coding gene Chr5:95535337-95536285 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027394
 protein coding gene Chr5:83941714-83942666 (+)
CAST/EiJ MGP_CASTEiJ_G0028837
 protein coding gene Chr5:90890752-90891699 (+)
CBA/J MGP_CBAJ_G0029397
 protein coding gene Chr5:98807414-98808362 (+)
DBA/2J MGP_DBA2J_G0029541
 protein coding gene Chr5:88311817-88312765 (+)
FVB/NJ MGP_FVBNJ_G0029500
 protein coding gene Chr5:87171812-87172760 (+)
LP/J MGP_LPJ_G0029629
 protein coding gene Chr5:92241967-92242915 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029529
 protein coding gene Chr5:103790742-103791690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030192
 protein coding gene Chr5:90640609-90641557 (+)
PWK/PhJ MGP_PWKPhJ_G0028556
 protein coding gene Chr5:87370699-87371647 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028391
 protein coding gene Chr5:90058646-90059590 (+)
WSB/EiJ MGP_WSBEiJ_G0028916
 protein coding gene Chr5:91099375-91100323 (+)



Homology
more
  • Human Ortholog
    PF4, platelet factor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PF4, platelet factor 4
  • Synonyms
    CXCL4, PF-4, SCYB4
  • Links
    NCBI Gene ID: 5196
    neXtProt AC: NX_P02776
    UniProt: P02776

  • Chr Location
    4q13.3; chr4:73980811-73982124 (-)  GRCh38
  • Human Ortholog
    PF4V1, platelet factor 4 variant 1
  • Synonyms
    CXCL4L1, CXCL4V1, PF4A, PF4-ALT, SCYB4V1
  • Links
    NCBI Gene ID: 5197
    neXtProt AC: NX_P10720
    UniProt: P10720

  • Chr Location
    4q13.3; chr4:73853296-73854483 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    50
  • cDNA Data
    32
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56744 NCBI Gene Model | MGI Sequence Detail 881 C57BL/6J ±  kb
transcript NM_019932 RefSeq | MGI Sequence Detail 520 C57BL/6  
polypeptide Q9Z126 UniProt | EBI | MGI Sequence Detail 105 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 32
    Primer pair 6
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 99
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 46
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:341634 Pokrajac NT, et al., Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation. Dev Cell. 2023 Oct 23;58(20):2015-2031.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory