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Cyp2c23 Gene Detail
Summary
  • Symbol
    Cyp2c23
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 23
  • Synonyms
    Cyp2c44, MGC:25860, MGC:37835, MGC:37849
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888897
    NCBI Gene: 226143
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43993461-44017647 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    776 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888897
 protein coding gene Chr19:43993461-44017695 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025161
 protein coding gene Chr19:43451679-43480982 (-)
A/J MGP_AJ_G0025138
 protein coding gene Chr19:41377978-41402746 (-)
AKR/J MGP_AKRJ_G0025106
 protein coding gene Chr19:42686430-42714018 (-)
BALB/cJ MGP_BALBcJ_G0025132
 protein coding gene Chr19:41423354-41448115 (-)
C3H/HeJ MGP_C3HHeJ_G0024892
 protein coding gene Chr19:42861813-42887282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025575
 protein coding gene Chr19:44510627-44543845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022989
 protein coding gene Chr19:40673403-40695570 (-)
CAST/EiJ MGP_CASTEiJ_G0024357
 protein coding gene Chr19:42566994-42599461 (-)
CBA/J MGP_CBAJ_G0024872
 protein coding gene Chr19:46721664-46762747 (-)
DBA/2J MGP_DBA2J_G0025004
 protein coding gene Chr19:41202020-41227688 (-)
FVB/NJ MGP_FVBNJ_G0024965
 protein coding gene Chr19:40964986-40988992 (-)
LP/J MGP_LPJ_G0025090
 protein coding gene Chr19:43409431-43437822 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024996
 protein coding gene Chr19:46249651-46279932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025633
 protein coding gene Chr19:42773973-42799721 (-)
PWK/PhJ MGP_PWKPhJ_G0024106
 protein coding gene Chr19:41103577-41128863 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023910
 protein coding gene Chr19:41489943-41514833 (-)
WSB/EiJ MGP_WSBEiJ_G0024427
 protein coding gene Chr19:42909830-42939466 (-)



Homology
more
  • Human Ortholog
    CYP2C23P, cytochrome P450 family 2 subfamily C member 23, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2C23P, cytochrome P450 family 2 subfamily C member 23, pseudogene
  • Synonyms
    CYP2C62P
  • Links
    NCBI Gene ID: 107436076

  • Chr Location
    10q24.31; chr10:100105754-100140151 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele show reduced proliferative and tubulogenic responses in lung endothelial cells, decreased tumor angiogenesis and growth of induced tumors, and high potassium-induced hypertension with decreased urinary sodium excretion and increased plasma sodium levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    98
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025197 Ensembl Gene Model | MGI Sequence Detail 24187 C57BL/6J ±  kb
    transcript ENSMUST00000026211 Ensembl | MGI Sequence Detail 1916 Not Applicable  
    polypeptide ENSMUSP00000026211 Ensembl | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147705, MGI:2675854, MGI:5910920
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory