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Akirin2 Gene Detail
Summary
  • Symbol
    Akirin2
  • Name
    akirin 2
  • Synonyms
    2700059D21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889364
    NCBI Gene: 433693
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:34550937-34566908 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 16.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889364
 protein coding gene Chr4:34550615-34566930 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028126
 protein coding gene Chr4:32134016-32150862 (+)
A/J MGP_AJ_G0028084
 protein coding gene Chr4:30952147-30967771 (+)
AKR/J MGP_AKRJ_G0028047
 protein coding gene Chr4:31776510-31792046 (+)
BALB/cJ MGP_BALBcJ_G0028095
 protein coding gene Chr4:31241560-31257418 (+)
C3H/HeJ MGP_C3HHeJ_G0027824
 protein coding gene Chr4:32092885-32109045 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028537
 protein coding gene Chr4:33357421-33375881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025878
 protein coding gene Chr4:29077367-29093635 (+)
CAST/EiJ MGP_CASTEiJ_G0027279
 protein coding gene Chr4:31882016-31900391 (+)
CBA/J MGP_CBAJ_G0027796
 protein coding gene Chr4:34430890-34449524 (+)
DBA/2J MGP_DBA2J_G0027940
 protein coding gene Chr4:30947453-30963083 (+)
FVB/NJ MGP_FVBNJ_G0027906
 protein coding gene Chr4:30363084-30378574 (+)
LP/J MGP_LPJ_G0028048
 protein coding gene Chr4:32219798-32236382 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027939
 protein coding gene Chr4:37041174-37056682 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028596
 protein coding gene Chr4:31802647-31820175 (+)
PWK/PhJ MGP_PWKPhJ_G0026998
 protein coding gene Chr4:30956757-30972937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026827
 protein coding gene Chr4:31663871-31679262 (+)
WSB/EiJ MGP_WSBEiJ_G0027355
 protein coding gene Chr4:31803660-31820162 (+)



Homology
more
  • Human Ortholog
    AKIRIN2, akirin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKIRIN2, akirin 2
  • Synonyms
    C6orf166, dJ486L4.2, FBI1
  • Links
    NCBI Gene ID: 55122
    neXtProt AC: NX_Q53H80
    UniProt: Q53H80

  • Chr Location
    6q15; chr6:87674860-87702233 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically and radiation induced
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    11
  • Targeted
    3
  • Genomic Mutations
    1 involving Akirin2
  • Find Mice (IMSR)
    23 strains or lines available
No homozygous null embryos are recovered at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028291 Ensembl Gene Model | MGI Sequence Detail 15972 C57BL/6J ±  kb
transcript ENSMUST00000084299 Ensembl | MGI Sequence Detail 1397 Not Applicable  
polypeptide ENSMUSP00000081322 Ensembl | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914435, MGI:2140455, MGI:3034236
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:327544 Peek SL, et al., p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2. iScience. 2022 Feb 18;25(2):103814
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory