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Crlf2 Gene Detail
Summary
  • Symbol
    Crlf2
  • Name
    cytokine receptor-like factor 2
  • Synonyms
    Ly114, Tpte2, Tslpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889506
    NCBI Gene: 57914
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:109702575-109706859 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889506
 protein coding gene Chr5:109702575-109707301 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029874
 protein coding gene Chr5:111872909-111880211 (-)
A/J MGP_AJ_G0029839
 protein coding gene Chr5:107534832-107539095 (-)
AKR/J MGP_AKRJ_G0029779
 protein coding gene Chr5:110933845-110938098 (-)
BALB/cJ MGP_BALBcJ_G0029851
 protein coding gene Chr5:108753282-108757845 (-)
C3H/HeJ MGP_C3HHeJ_G0029572
 protein coding gene Chr5:111403507-111408466 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030302
 protein coding gene Chr5:116319503-116323834 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028980
 protein coding gene Chr5:110249512-110289778 (-)
CBA/J MGP_CBAJ_G0029539
 protein coding gene Chr5:120450052-120457075 (-)
DBA/2J MGP_DBA2J_G0029688
 protein coding gene Chr5:107599397-107603597 (-)
FVB/NJ MGP_FVBNJ_G0029645
 protein coding gene Chr5:106336045-106341129 (-)
LP/J MGP_LPJ_G0029775
 protein coding gene Chr5:112384800-112388949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029674
 protein coding gene Chr5:125216964-125221028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030341
 protein coding gene Chr5:110427389-110431532 (-)
PWK/PhJ MGP_PWKPhJ_G0028694
 protein coding gene Chr5:106273904-106281939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028531
 protein coding gene Chr5:108000636-108004885 (-)
WSB/EiJ MGP_WSBEiJ_G0029055
 protein coding gene Chr5:110885252-110889882 (-)



Homology
more
  • Human Ortholog
    CRLF2, cytokine receptor like factor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRLF2, cytokine receptor like factor 2
  • Synonyms
    CRL2, CRLF2Y, TSLPR
  • Links
    NCBI Gene ID: 64109
    neXtProt AC: NX_Q9HC73
    UniProt: Q9HC73

  • Chr Location
    XY;Y
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are overtly normal and maintain normal lymphopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    16
  • cDNA Data
    39
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033467 Ensembl Gene Model | MGI Sequence Detail 4285 C57BL/6J ±  kb
    transcript ENSMUST00000044579 Ensembl | MGI Sequence Detail 1323 Not Applicable  
    polypeptide ENSMUSP00000036326 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1355298
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 120
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345793 Malinczak CA, et al., Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs. Am J Physiol Lung Cell Mol Physiol. 2024 Mar 1;326(3):L280-L291
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory