About   Help   FAQ
Slco1c1 Gene Detail
Summary
  • Symbol
    Slco1c1
  • Name
    solute carrier organic anion transporter family, member 1c1
  • Synonyms
    OATP-F, Slc21a14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889679
    NCBI Gene: 58807
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:141470094-141515903 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 72.38 cM, cytoband G1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1769 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889679
 protein coding gene Chr6:141470080-141515903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031452
 protein coding gene Chr6:146283497-146330566 (+)
A/J MGP_AJ_G0031427
 protein coding gene Chr6:140495563-140541451 (+)
AKR/J MGP_AKRJ_G0031355
 protein coding gene Chr6:144706598-144753338 (+)
BALB/cJ MGP_BALBcJ_G0031434
 protein coding gene Chr6:140329742-140375075 (+)
C3H/HeJ MGP_C3HHeJ_G0031156
 protein coding gene Chr6:144769413-144820295 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031896
 protein coding gene Chr6:150279620-150326328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029026
 protein coding gene Chr6:139334721-139381142 (+)
CAST/EiJ MGP_CASTEiJ_G0030524
 protein coding gene Chr6:144325827-144374916 (+)
CBA/J MGP_CBAJ_G0031116
 protein coding gene Chr6:156014238-156063994 (+)
DBA/2J MGP_DBA2J_G0031273
 protein coding gene Chr6:139336102-139382118 (+)
FVB/NJ MGP_FVBNJ_G0031224
 protein coding gene Chr6:138126875-138173498 (+)
LP/J MGP_LPJ_G0031357
 protein coding gene Chr6:146424687-146471604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031264
 protein coding gene Chr6:159880882-159932211 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031928
 protein coding gene Chr6:144538101-144592562 (+)
PWK/PhJ MGP_PWKPhJ_G0030251
 protein coding gene Chr6:137841513-137883587 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030075
 protein coding gene Chr6:142763406-142815786 (+)
WSB/EiJ MGP_WSBEiJ_G0030617
 protein coding gene Chr6:145183734-145233430 (+)



Homology
more
  • Human Ortholog
    SLCO1C1, solute carrier organic anion transporter family member 1C1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO1C1, solute carrier organic anion transporter family member 1C1
  • Synonyms
    OATP1, OATP14, OATP1C1, OATP-F, OATPF, OATP-RP5, OATPRP5, SLC21A14
  • Links
    NCBI Gene ID: 53919
    neXtProt AC: NX_Q9NYB5
    UniProt: Q9NYB5

  • Chr Location
    12p12.2; chr12:20695332-20753386 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased thyroxine and triiodothyronine levels in the forebrain, in the absence of overt growth, reproductive or neurological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1076
  • Tissues
    85
  • cDNA Data
    9
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030235 Ensembl Gene Model | MGI Sequence Detail 45810 C57BL/6J ±  kb
transcript ENSMUST00000032362 Ensembl | MGI Sequence Detail 3178 Not Applicable  
polypeptide ENSMUSP00000032362 Ensembl | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 11
    Primer pair 4

    Microarray probesets 4
References
more
  • Summaries
    All 52
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:102103 Jensen P, et al., A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
  • Latest
    J:343802 Siemes D, et al., Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function. Cells. 2023 Oct 19;12(20)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory