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Hibadh Gene Detail
Summary
  • Symbol
    Hibadh
  • Name
    3-hydroxyisobutyrate dehydrogenase
  • Synonyms
    6430402H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889802
    NCBI Gene: 58875
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52523215-52617285 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2076 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889802
 protein coding gene Chr6:52523213-52617374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030752
 protein coding gene Chr6:51821397-51921996 (-)
A/J MGP_AJ_G0030721
 protein coding gene Chr6:49400529-49495368 (-)
AKR/J MGP_AKRJ_G0030648
 protein coding gene Chr6:51112950-51211974 (-)
BALB/cJ MGP_BALBcJ_G0030733
 protein coding gene Chr6:49747061-49842467 (-)
C3H/HeJ MGP_C3HHeJ_G0030446
 protein coding gene Chr6:51121803-51217447 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031188
 protein coding gene Chr6:52961234-53063069 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028394
 protein coding gene Chr6:47024954-47124395 (-)
CAST/EiJ MGP_CASTEiJ_G0029849
 protein coding gene Chr6:50935693-51038942 (-)
CBA/J MGP_CBAJ_G0030420
 protein coding gene Chr6:55182955-55286027 (-)
DBA/2J MGP_DBA2J_G0030570
 protein coding gene Chr6:49313795-49407725 (-)
FVB/NJ MGP_FVBNJ_G0030522
 protein coding gene Chr6:48914052-49008235 (-)
LP/J MGP_LPJ_G0030655
 protein coding gene Chr6:51776754-51877111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030556
 protein coding gene Chr6:57781762-57899483 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031218
 protein coding gene Chr6:51053019-51154022 (-)
PWK/PhJ MGP_PWKPhJ_G0029562
 protein coding gene Chr6:48935220-49029273 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029396
 protein coding gene Chr6:50371675-50470982 (-)
WSB/EiJ MGP_WSBEiJ_G0029926
 protein coding gene Chr6:51050390-51148744 (-)



Homology
more
  • Human Ortholog
    HIBADH, 3-hydroxyisobutyrate dehydrogenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIBADH, 3-hydroxyisobutyrate dehydrogenase
  • Synonyms
    NS5ATP1
  • Links
    NCBI Gene ID: 11112
    neXtProt AC: NX_P31937
    UniProt: P31937

  • Chr Location
    7p15.2; chr7:27525442-27662883 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    64
  • cDNA Data
    176
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58875 NCBI Gene Model | MGI Sequence Detail 94071 C57BL/6J ±  kb
    transcript NM_145567 RefSeq | MGI Sequence Detail 1748 Not Specified  
    polypeptide Q99L13 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008549 3-hydroxyisobutyrate dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.1.1.31
    • InterPro Domains
      IPR011548 3-hydroxyisobutyrate dehydrogenase
      IPR029154 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain
      IPR015815 3-hydroxyisobutyrate dehydrogenase-related
      IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      Q99L13 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 178
      cDNA 176
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory