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Tspan12 Gene Detail
Summary
  • Symbol
    Tspan12
  • Name
    tetraspanin 12
  • Synonyms
    Tm4sf12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889818
    NCBI Gene: 269831
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:21771394-21852514 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 8.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2457 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889818
 protein coding gene Chr6:21771390-21879557 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030480
 protein coding gene Chr6:19237672-19321230 (-)
A/J MGP_AJ_G0030453
 protein coding gene Chr6:18448619-18537061 (-)
AKR/J MGP_AKRJ_G0030380
 protein coding gene Chr6:19005837-19096534 (-)
BALB/cJ MGP_BALBcJ_G0030462
 protein coding gene Chr6:18535283-18609462 (-)
C3H/HeJ MGP_C3HHeJ_G0030176
 protein coding gene Chr6:18984089-19076442 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030917
 protein coding gene Chr6:19824868-19907146 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028128
 protein coding gene Chr6:17081863-17155104 (-)
CAST/EiJ MGP_CASTEiJ_G0029578
 protein coding gene Chr6:18873840-18992017 (-)
CBA/J MGP_CBAJ_G0030154
 protein coding gene Chr6:20482285-20565906 (-)
DBA/2J MGP_DBA2J_G0030298
 protein coding gene Chr6:18357113-18437811 (-)
FVB/NJ MGP_FVBNJ_G0030252
 protein coding gene Chr6:18149073-18231041 (-)
LP/J MGP_LPJ_G0030385
 protein coding gene Chr6:19335409-19414660 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030288
 protein coding gene Chr6:22303134-22397113 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030947
 protein coding gene Chr6:18982356-19070978 (-)
PWK/PhJ MGP_PWKPhJ_G0029292
 protein coding gene Chr6:18035433-18115304 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029128
 protein coding gene Chr6:18698408-18828555 (-)
WSB/EiJ MGP_WSBEiJ_G0029654
 protein coding gene Chr6:18869295-18952909 (-)



Homology
more
  • Human Ortholog
    TSPAN12, tetraspanin 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN12, tetraspanin 12
  • Synonyms
    EVR5, NET-2, NET2, TM4SF12
  • Links
    NCBI Gene ID: 23554
    neXtProt AC: NX_O95859
    UniProt: O95859

  • Chr Location
    7q31.31; chr7:120787320-120858402 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tspan12 mouse models; 1 with human TSPAN12 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal retinal vasculature with pericapillary occlusions, lack of vertical sprouts, gliosis, fenestration, microanurysms, hemorrhage, and delayed regression of hyaloid capillaries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    63
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029669 Ensembl Gene Model | MGI Sequence Detail 81121 C57BL/6J ±  kb
    transcript ENSMUST00000031678 Ensembl | MGI Sequence Detail 2490 Not Applicable  
    polypeptide ENSMUSP00000031678 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141465, MGI:2141646
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339192 Zhang L, et al., A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response. iScience. 2023 Aug 18;26(8):107415
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory