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Zfp110 Gene Detail
Summary
  • Symbol
    Zfp110
  • Name
    zinc finger protein 110
  • Synonyms
    2900024E01Rik, NRIF, Nrif1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890378
    NCBI Gene: 65020
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:12568688-12584504 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890378
 protein coding gene Chr7:12565225-12584513 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031653
 protein coding gene Chr7:10227787-10243638 (+)
A/J MGP_AJ_G0031626
 protein coding gene Chr7:10076605-10093168 (+)
AKR/J MGP_AKRJ_G0031549
 protein coding gene Chr7:10303825-10319487 (+)
BALB/cJ MGP_BALBcJ_G0031631
 protein coding gene Chr7:10183117-10198955 (+)
C3H/HeJ MGP_C3HHeJ_G0031353
 protein coding gene Chr7:10397199-10414710 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032095
 protein coding gene Chr7:10751040-10766866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029189
 protein coding gene Chr7:11670110-11685714 (+)
CAST/EiJ MGP_CASTEiJ_G0030711
 protein coding gene Chr7:7949482-7967413 (+)
CBA/J MGP_CBAJ_G0031310
 protein coding gene Chr7:10962417-10978266 (+)
DBA/2J MGP_DBA2J_G0031468
 protein coding gene Chr7:9959443-9975127 (+)
FVB/NJ MGP_FVBNJ_G0031424
 protein coding gene Chr7:9955404-9971312 (+)
LP/J MGP_LPJ_G0031555
 protein coding gene Chr7:10314476-10332422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031459
 protein coding gene Chr7:11054974-11070867 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032125
 protein coding gene Chr7:10081404-10097069 (+)
PWK/PhJ MGP_PWKPhJ_G0030439
 protein coding gene Chr7:8444674-8460707 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030265
 protein coding gene Chr7:6180887-6197689 (+)
WSB/EiJ MGP_WSBEiJ_G0030806
 protein coding gene Chr7:10105007-10121406 (+)



Homology
more
  • Human Ortholog
    ZNF274, zinc finger protein 274
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF274, zinc finger protein 274
  • Synonyms
    HFB101, ZF2, ZKSCAN19, ZSCAN51
  • Links
    NCBI Gene ID: 10782
    neXtProt AC: NX_Q96GC6
    UniProt: Q96GC6

  • Chr Location
    19q13.43; chr19:58183029-58213562 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants on a C57BL/6 background die at embryonic day 12. On a strain 129 background, mutants are viable and fertile, but males are more docile and testis weight is greatly reduced. On an F2 background, 20% of homozygous pups die neonatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    57
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058638 Ensembl Gene Model | MGI Sequence Detail 15817 C57BL/6J ±  kb
    transcript ENSMUST00000004614 Ensembl | MGI Sequence Detail 3591 Not Applicable  
    polypeptide ENSMUSP00000004614 Ensembl | MGI Sequence Detail 832 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920172, MGI:2142379
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:66924 Casademunt E, et al., The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. EMBO J. 1999 Nov 1;18(21):6050-61
    • Latest
      J:199694 Liang Y, et al., Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. Nucleic Acids Res. 2012 Sep 1;40(17):8721-32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory