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Ear10 Gene Detail
Summary
  • Symbol
    Ear10
  • Name
    eosinophil-associated, ribonuclease A family, member 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890464
    NCBI Gene: 93725
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:44160355-44161053 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890464
 protein coding gene Chr14:44160177-44161053 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0021212
 protein coding gene Chr14:46278066-46278656 (+)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0021175
 protein coding gene Chr14:45515348-45516188 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020116
 protein coding gene Chr14:41697961-41698505 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE2, ribonuclease A family member 2
  • Synonyms
    EDN, RAF3, RNS2
  • Links
    NCBI Gene ID: 6036
    neXtProt AC: NX_P10153
    UniProt: P10153

  • Chr Location
    14q11.2; chr14:20955487-20956436 (+)  GRCh38
  • Human Ortholog
    RNASE3, ribonuclease A family member 3
  • Synonyms
    ECP, RAF1, RNS3
  • Links
    NCBI Gene ID: 6037
    neXtProt AC: NX_P12724
    UniProt: P12724

  • Chr Location
    14q11.2; chr14:20891385-20892348 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 93725 NCBI Gene Model | MGI Sequence Detail 699 C57BL/6J ±  kb
transcript NM_053112 RefSeq | MGI Sequence Detail 699 C57BL/6  
polypeptide NP_444342 RefSeq | MGI Sequence Detail 156 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001427 Pancreatic ribonuclease
    IPR023411 Ribonuclease A, active site
    IPR023412 Ribonuclease A-domain
    IPR036816 Ribonuclease A-like domain superfamily
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 15
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:69087 Cormier SA, et al., Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome. 2001 May;12(5):352-61
  • Latest
    J:237813 Chen JQ, et al., Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. PLoS One. 2015;10(6):e0129895
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory