About   Help   FAQ
Laptm4b Gene Detail
Summary
  • Symbol
    Laptm4b
  • Name
    lysosomal-associated protein transmembrane 4B
  • Synonyms
    C330023P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890494
    NCBI Gene: 114128
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:34238279-34284448 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 13.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890494
 protein coding gene Chr15:34238174-34284448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021776
 protein coding gene Chr15:32525868-32575576 (+)
A/J MGP_AJ_G0021737
 protein coding gene Chr15:31288084-31335478 (+)
AKR/J MGP_AKRJ_G0021714
 protein coding gene Chr15:32128460-32178070 (+)
BALB/cJ MGP_BALBcJ_G0021743
 protein coding gene Chr15:31295834-31342189 (+)
C3H/HeJ MGP_C3HHeJ_G0021518
 protein coding gene Chr15:32110502-32159786 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022182
 protein coding gene Chr15:33771678-33824064 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019720
 protein coding gene Chr15:29179190-29226753 (+)
CAST/EiJ MGP_CASTEiJ_G0021034
 protein coding gene Chr15:32518431-32569360 (+)
CBA/J MGP_CBAJ_G0021487
 protein coding gene Chr15:34811463-34870585 (+)
DBA/2J MGP_DBA2J_G0021611
 protein coding gene Chr15:31094442-31142368 (+)
FVB/NJ MGP_FVBNJ_G0021589
 protein coding gene Chr15:30548762-30595094 (+)
LP/J MGP_LPJ_G0021680
 protein coding gene Chr15:32416045-32471105 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021614
 protein coding gene Chr15:37852021-37903848 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022205
 protein coding gene Chr15:32319589-32373257 (+)
PWK/PhJ MGP_PWKPhJ_G0020778
 protein coding gene Chr15:31134101-31182177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020616
 protein coding gene Chr15:32010060-32058269 (+)
WSB/EiJ MGP_WSBEiJ_G0021090
 protein coding gene Chr15:32300115-32346879 (+)



Homology
more
  • Human Ortholog
    LAPTM4B, lysosomal protein transmembrane 4 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAPTM4B, lysosomal protein transmembrane 4 beta
  • Synonyms
    LAPTM4beta, LC27
  • Links
    NCBI Gene ID: 55353
    neXtProt AC: NX_Q86VI4
    UniProt: Q86VI4

  • Chr Location
    8q22.1; chr8:97775057-97853013 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects cardiomyocyte cell death, leading to exacerbation of ischemia-induced cardiac infarction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    30
  • cDNA Data
    151
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114128 NCBI Gene Model | MGI Sequence Detail 46170 C57BL/6J ±  kb
    transcript NM_033521 RefSeq | MGI Sequence Detail 1797 C57BL/6  
    polypeptide Q91XQ6 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000029588 lysosomal-associated transmembrane protein 4B
      (term hierarchy)
    • InterPro Domains
      IPR004687 Lysosomal-associated transmembrane protein 4/5
      IPR051115 Lysosomal-associated transmembrane transporter
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 152

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915361
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory